Vayots Dzor is a province of Armenia. It lies at the southeastern end of the country, bordering the Nakhchivan exclave of Azerbaijan to the west and the Kalbajar District of Azerbaijan to the east. It covers an area of 2,308 km2 (891 sq mi). With a population of only 52,324 (2011 census), it is the most sparsely populated province in the country. The capital and largest city of the province is the town of Yeghegnadzor.
The province is home to many ancient landmarks and tourist attractions in Armenia including the Areni-1 cave complex and Areni-1 winery of the Chalcolithic period, the 8th-century Tanahat Monastery, the 10th-century fortress of Smbataberd, and the 13th-century monastery of Noravank. Vayots Dzor is also home to the spa-town of Jermuk.
The village of Gladzor in Vayots Dzor was home to the 13th and 14th-century University of Gladzor.