Gegharkunik Province is located at the eastern part of Armenia, bordering Azerbaijan. It includes the exclave of Artsvashen, which has been under Azerbaijani occupation since the First Nagorno-Karabakh War. With an area of 5,348 km2(2,065 sq mi), Gegharkunik is the largest province in Armenia. However, approximately 24% or 1,278 km2(493 sq mi) of its territory is covered by Lake Sevan, the largest lake in the South Caucasus and a major tourist attraction of the region.

The Yerevan-Sevan-Dilijan republican highway runs through the province.